Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens.

Western

Western blot analysis of REA in K562, rat Brain, C6, 3T3, Hela lysates using REA antibody.

Immunocytochemistry

Immunocytochemistry analysis of REA(green) in Hela using REA antibody,and DAPI(blue)

Immunohistochemistry

Immunohistochemistry analysis of paraffin-embedded Human colon cancer using REA antibody. High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.