IBMX (3-Isobutyl-1-methylxanthine, Isobutylmethylxanthine, NSC165960, SC2964, NSC-165960, SC-2964),又称3-异丁基-1-甲基黄嘌呤,是非特异的磷酸二酯酶(PDE)抑制剂,作用于PDE3/4/5,IC50分别为6.5 μM、26.3 μM和31.7 μM。它能增强细胞内cAMP和cGMP水平,激活AGC蛋白激酶(PKA)。IBMX还能与腺苷受体结合,拮抗天然激动剂的抑制作用。
参考文献
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冰袋运输。粉末直接保存于-20℃,有效期3年。建议分装后-20℃干燥保存,避免反复冻融。