Ginkgolide B (BN52021, BN-52021),又称银杏内酯B或白果苦内酯B,是从银杏中提取的一种二萜内酯类化合物,是PAFR拮抗剂,是血小板活化因子拮抗剂,可在临床上用于治疗心血管疾病,也具有抗癌作用。
参考文献
[1] Lamant V, et al. Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. Biochem Pharmacol. 1987 Sep 1;36(17):2749-52.
[2] Tang Y, et al. Ginkgolide B promotes proliferation and functional activities of bone marrow-derived endothelial progenitor cells: involvement of Akt/eNOS and MAPK/p38 signaling pathwayst. Eur Cell Mater. 2011 May 28;21:459-69.
[3] Gu JH, et al. Inhibition of NF-κB activation is associated with anti-inflammatory and anti-apoptotic effects of Ginkgolide B in a mouse model of cerebral ischemia/reperfusion injury. Eur J Pharm Sci. 2012 Nov 20;47(4):652-60.
冰袋运输。粉末直接保存于-25~-15℃,有效期3年。建议分装后-25~-15℃干燥保存,避免反复冻融。
Q:怎么溶解?溶解度是多少呢?
A:DMSO,大约30-40mg/ml。